2,7-anhydro-N-acetylneuraminate hydratase

UniProtKB accession:  P39353

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Hydratase involved in the degradation of sialic acids (PubMed:32542330, PubMed:32669363). Catalyzes the reversible conversion of the dehydrated form of N-acetylneuraminate (Neu5Ac), 2,7-anhydro-N-acetylneuraminate (2,7-AN), to Neu5Ac (PubMed:32542330, PubMed:32669363). Also catalyzes the irreversible conversion of 2-deoxy-2,3-didehydro-N-acetylneuraminate (2,3-EN) to Neu5Ac (PubMed:32542330). The reaction mechanism involves keto intermediates and the transient formation of NADH (PubMed:32542330).