Tyrosine--tRNA ligase, cytoplasmic

UniProtKB accession:  P36421

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Catalyzes the attachment of L-tyrosine to tRNA(Tyr) in a two-step reaction: L-tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (PubMed:8509419, PubMed:3535890, PubMed:10588711, PubMed:10677221, PubMed:10766779). The specificity determinants on tRNA(Tyr) are the base pair C1-G72, the discriminator residue A73, and the three anticodon bases G34, U35 and A36 (PubMed:10677221). Also involved in nuclear tRNA export (PubMed:10588711). Also attaches D-Tyr to tRNA(Tyr), this reaction is about 150-fold less efficient than attachment of L-Tyr (PubMed:10766779).