Drosocin antimicrobial peptides

UniProtKB accession:  P36193

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Antibacterial peptide with strong anti-Gram-negative bacteria activity (PubMed:8325867). Significantly contributes to antibacterial activity against Enterobacter cloacae but not Providencia burhodogranariea (PubMed:35730150). Inhibitor of bacterial translation machinery that targets translation termination in a prfA- or prfB-dependent manner (PubMed:36997646). Binds within the nascent peptide exit tunnel of the bacterial large ribosomal subunit, potentially interfering with nascent chain translocation that occurs post-peptide bond formation (PubMed:36997646, PubMed:36997647). Binds prfA/RF1 (and potentially prfB/RF2), trapping it on the ribosome after release of the nascent polypeptide chain and preventing further translation (PubMed:36997646). The resulting depletion of peptide chain release factors further disrupts bacterial translation by preventing ribosomal peptide chain release and inducing stop codon readthrough (PubMed:36997647). Entry into target Escherichia coli cells requires the bacterial peptide antibiotic transporter sbmA (PubMed:36997646).