Endonuclease CUE2

UniProtKB accession:  P36075

Grouped By:  Matching UniProtKB accession

UniProtKB description:  mRNA endonuclease involved in the No-Go Decay (NGD) pathway, which catalyzes mRNA cleavage and degradation in response to ribosome collisions (PubMed:31219035, PubMed:36583309). Acts downstream of the ribosome collision sensor HEL2 (PubMed:36583309). Specifically recognizes and binds RPS7/eS7 polyubiquitinated by MOT2/NOT4 and HEL2, promoting CUE2 recruitment to stalled ribosomes, where it mediates mRNA cleavage upstream of the colliding ribosome (PubMed:36583309). Also mediates mRNA cleavage within colliding ribosomes: recruited to colliding ribosomes downstream of the RQT (ribosome quality control trigger) complex following disassembly of stalled ribosomes and cleaves mRNAs partially released from the colliding ribosome (PubMed:36583309).