Protein skinhead-1

UniProtKB accession:  P34707

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Transcription factor (PubMed:1547503, PubMed:28600327). Required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine (PubMed:1547503). Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development (PubMed:1547503, PubMed:11463373). In response to oxidative stress and anoxia, required to up-regulate expression of stl-1 mRNA (PubMed:24385935). Involved in regulating innate immunity, acting downstream of the pmk-1 p38/MAPK pathway and probably also downstream of nipi-3 (PubMed:34407394). Required for the up-regulation of phase II detoxification genes, including gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection (PubMed:22216003). Modulates oxidative stress responses in concert with transcription factors such as hcf-1 and elt-3 (PubMed:22568582, PubMed:28600327). Regulates the transcription of genes associated with metabolism in response to changes in nutrient availability (PubMed:23040073). In neurons, involved in mitochondrial fusion and behavioral recovery during reoxygenation (PubMed:24385935). Required for riok-1 mRNA expression in the intestine (PubMed:25688864). Downstream of the let-60/Ras, mek-2 and pmk-1 pathway, positively regulates lifespan probably by preventing transcription of insulin-like peptides such as ins-39 (PubMed:20624915). Prevents degeneration of dopaminergic CEP neurons in response to high Al(3+) or Mn(2+) levels, probably by promoting the expression of glutathione-S-transferase gst-1 (PubMed:23106139, PubMed:23721876).