Phospholipid-transporting ATPase DNF1

UniProtKB accession:  P32660

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide, phosphatidylcholine, phosphatidylethanolamine, and small amounts of phosphatidylserine from the lumenal to the cytosolic leaflet of the cell membrane and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:22791719, PubMed:33320091, PubMed:12631737, PubMed:35294892, PubMed:31786280, PubMed:33060204, PubMed:22308393, PubMed:23302692). Does not appear to transport sphingomyelin, inositol phosphoceramide, or phosphatidic acid (PubMed:33320091, PubMed:12631737, PubMed:22308393). Required for efficient endocytosis (PubMed:12631737).