Protein KTI13
UniProtKB accession: P31386
Grouped By: Matching UniProtKB accession
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Go to UniProtKB: P31386
UniProtKB description: Together with KTI11; associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex (PubMed:18466297, PubMed:25543256). Association with the elongator complex is mediated via interaction with KTI11 (PubMed:18466297, PubMed:25543256). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:25543256). Together with KTI11; also required for diphthamide biosynthesis; diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:25543256). May participate in regulatory interactions between microtubules and the cell cycle (PubMed:8070652).
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