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E3 ubiquitin-protein ligase ICP0

UniProtKB accession:  P28990
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Go to UniProtKB:  P28990
UniProtKB description:  Evades nuclear antiviral defenses triggered by dsDNA viruses. Acts during the initial stages of lytic infection and the reactivation of latent viral genome. Prevents the antiviral effect of nuclear bodies by degrading host PML and SP100.
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