Outer mitochondrial transmembrane helix translocase

UniProtKB accession:  P28737

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (PubMed:24843043, PubMed:24821790, PubMed:28906250, PubMed:30858337, PubMed:31445887, PubMed:28712723). Specifically recognizes and binds exposed hydrophobic surfaces of mistargeted tail-anchored transmembrane proteins (PubMed:30858337). Acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (PubMed:24843043, PubMed:24821790, PubMed:28906250, PubMed:30858337, PubMed:32541053, PubMed:28712723). Able to unfold protein substrates by processive threading through its central pore (PubMed:32541053). Once extracted from the mitochondrion outer membrane, substrate proteins are then transferred to the endoplasmic reticulum, where they are ubiquitinated and degraded by the proteasome (PubMed:31445887). Also mediates extraction of excess tail-anchored proteins from the peroxisomal membrane (PubMed:28906250). In normal conditions, MSP1 translocase activity is inhibited by PEX3 at peroxisomes; only catalyzes removal of excess tail-anchored proteins (PubMed:28906250).