Serine/threonine-protein kinase VPS15

UniProtKB accession:  P22219

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I (PubMed:11157979). This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure (PubMed:11157979, PubMed:1988155, PubMed:1756716, PubMed:7989323). Is also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II (PubMed:8649377, PubMed:11157979, PubMed:12244127). This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes) (PubMed:12244127, PubMed:8387919, PubMed:8509446, PubMed:7989323, PubMed:8649377). By regulating VPS34 kinase activity, VPS15 appears to be essential for the efficient delivery of soluble hydrolases to the yeast vacuole (PubMed:8387919, PubMed:8509446). May function as a G protein beta subunit to propagate the pheromone response at the endosome with GPA1 (PubMed:19445518).