Non-structural protein S

UniProtKB accession:  P21698

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Plays a role in the escape of host innate immune response by promoting the degradation of host EIF2AK2/PKR and inhibiting host transcription (PubMed:19751406, PubMed:19211744, PubMed:19197350). Cytoplasmic NSs interacts with host FBXW11 to degrade PKR whereas nuclear pool binds to host FBXO3 to target TFIIH subunit GTF2H1 for proteasomal degradation with the help of the linker protein SKP1 (PubMed:19211744, PubMed:21543505, PubMed:23063407, PubMed:26837067). Removes FBXO3 isoform 1 from the nucleus (PubMed:24403578). Forms nuclear amyloid-like filaments of about 12 nm in width that may sequester NSs binding partners, causing cell cycle arrest (PubMed:10233964, PubMed:28915104, PubMed:32612175). Also aggragates in the cytosol as short fibrils late after host cell infection (PubMed:32612175). Plays a role in cell morphology and/or motility, reduction of lamellipodia, cell spreading, and dissolution of adherens junctions (PubMed:33087469).