Anthraniloyl-CoA anthraniloyltransferase

UniProtKB accession:  P20582

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UniProtKB description:  Required for the biosynthesis of a number of signaling molecules, such as the quinolone signal 2-heptyl-3-hydroxy-4(1H)-quinolone (PQS), 2-heptyl-4-hydroxyquinoline (HHQ) and 2,4-dihydroxyquinoline (DHQ). These molecules are required for normal biofilm formation. Catalyzes the transfer of the anthraniloyl moiety from anthraniloyl-CoA to malonyl-CoA to form 2-aminobenzoylacetyl-CoA (PubMed:24239007). The first step of the reaction is the formation of a covalent anthraniloyl-PqsD intermediate (PubMed:18728009, PubMed:19694421). Next, the short-lived intermediate 3-(2-aminophenyl)-3-oxopropanoyl-CoA is formed. An intramolecular rearrangement of this intermediate can give rise to 2,4-dihydroxyquinoline (DHQ).