Vitamin D3 dihydroxylase

UniProtKB accession:  P18326

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UniProtKB description:  Involved in the metabolism of vitamin D3 (calciol) and of a number of sulfonylurea herbicides. Catalyzes the two-step hydroxylation (25- and 1-alpha-hydroxylation) of vitamin D3 (VD3) to yield its active form 1-alpha,25-dihydroxyvitamin D3 (calcitriol). The first step is the hydroxylation of the C-25 position of VD3 to produce 25-hydroxyvitamin D3 (calcidiol). The second reaction is the hydroxylation of the C1-alpha-position of calcidiol to produce calcitriol. It can also hydroxylate vitamin D2.