Tetracenomycin biosynthesis bifunctional cyclase/O-methyl transferase TcmN

UniProtKB accession:  P16559

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Involved in the biosynthesis of tetracenomycin C (TCM C) (PubMed:1548230, PubMed:9609708). Part of a type II polyketide synthase (PKS) that catalyzes the synthesis of tetracenomycin F2 (TCM F2), a precursor of TCM C, from malonyl-CoA (PubMed:8248801, PubMed:9609708). The TcmN N-terminal domain, when coupled with the other components of the PKS, catalyzes the cyclization and aromatization of the linear polyketide intermediate (PubMed:1548230, PubMed:8248801, PubMed:8692863, PubMed:18388203). Catalyzes the cyclization of the first and second rings (PubMed:18388203). In addition, the C-terminal domain acts as a methyltransferase (PubMed:1548230, PubMed:8692863). It catalyzes the specific O-methylation of tetracenomycin D3 (TCM D3) to TCM B3, using S-adenosyl-L-methionine as the methyl donor (PubMed:8692863).