Pre-baseplate central spike protein Gp5

UniProtKB accession:  P16009

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Baseplate central spike complex-associated lysozyme that is essential for the localized hydrolysis of bacterial cell wall, so that the tail tube, through which the phage DNA is ejected, can penetrate to the host inner membrane (PubMed:21129200, PubMed:21793574, PubMed:16956798, PubMed:3157805). The tail lysozyme complex at the tip of the tail tube penetrates through the outer membrane into the periplasm and during that process, gp5* dissociates from gp5C and activated (PubMed:16956798). Due to the lower pH in the periplasm, gp5* would dissociate from gp27 which probably still binds to the tip of the tube (PubMed:16956798). This way, lysozyme domain is released and locally digests the peptidoglycan layer to make a hole to let the tube penetrate to the inner membrane (PubMed:16956798). Involved in the tail assembly (PubMed:21129200).