Protein lin-12

UniProtKB accession:  P14585

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Essential signaling protein which has a major role in many developmental processes; involved in cell fate decisions that require cell-cell interactions (PubMed:3419531, PubMed:3000611). Probable membrane-bound receptor for putative ligands lag-2, apx-1, dsl-1 and osm-11 (PubMed:18036582, PubMed:18700817, PubMed:32053105, PubMed:3419531). Upon ligand activation, and releasing from the cell membrane, the lin-12/Notch intracellular domain (NICD) forms a transcriptional activator complex with lag-1 and lag-3 and regulates expression of various genes (PubMed:8343960, PubMed:7566091, PubMed:16197940, PubMed:10830967, PubMed:16530045, PubMed:18381292). Required for ventral cell fates in the postembryonic mesodermal lineage (M lineage) and in uterine precursor cells (PubMed:3419531, PubMed:18036582). Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10 (PubMed:9389650). Best known for involvement in cell-fate decisions during development, but also plays roles in other events (PubMed:10903169, PubMed:18599512, PubMed:21549604, PubMed:27661254). Regulates recovery from the dauer larval state (PubMed:18599512). Modulates chemosensory avoidance of octanol and quiescence during molting (PubMed:21549604). Promotes basement membrane mobility during tissue remodeling (PubMed:27661254). Involved in establishing left-right asymmetry during intestinal organogenesis (PubMed:10903169).