Vitamin D3 receptor

UniProtKB accession:  P13053

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:17227670). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (PubMed:17227670). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (By similarity).