L-aspartate oxidase

UniProtKB accession:  P10902

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+) (PubMed:2841129, PubMed:7033218, PubMed:2187483, PubMed:8706749, PubMed:8706750, PubMed:11294641). Can use either oxygen or fumarate as electron acceptors, which allows the enzyme to be functional under aerobic and anaerobic conditions (PubMed:8706750, PubMed:11294641, PubMed:12200425). In vivo, fumarate is used under anaerobic conditions, and oxygen is the predominant electron acceptor under aerobic conditions due to the lower fumarate levels (PubMed:20149100). In vitro, fumarate is a more efficient electron acceptor and is kinetically superior to oxygen (PubMed:12200425, PubMed:20149100).