Tegument protein VP22

UniProtKB accession:  P10233

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Tegument protein that plays different roles during the time course of infection (PubMed:22993164, PubMed:24131716, PubMed:9658087, PubMed:11967313). Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection (PubMed:22993164, PubMed:24131716, PubMed:9658087, PubMed:11967313). Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins (PubMed:22951838). Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network (PubMed:9658087, PubMed:11967313). Finally, may prevent nucleosomal deposition onto the viral genome by interacting with and inhibiting host SET (PubMed:12917472). Plays a role in the inhibition of host innate immune system by targeting the CGAS enzymatic activity which is the principal cytosolic DNA sensor that detects invading viral DNA (PubMed:29793952, PubMed:34015248). Acts by mediating disruption of liquid-like droplets in which CGAS is activated, thereby preventing CGAS activity (PubMed:34015248).