Omega-conotoxin Bu8

UniProtKB accession:  P0CY66

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UniProtKB description:  Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin selectively and potently inhibits depolarization-activated rat Cav2.2/CACNA1B currents (IC(50)=89 nM), when coexpressed with alpha-2/delta-1 (CACNA2D1) and beta-3 (CACNB3) subunits. In vivo, is lethal to fish and displays potent analgesic activity in mice pain models of hot plate and acetic acid writhing but has fewer side effects on mouse motor function and lower toxicity in goldfish. Shows higher or similar analgesic activity in the pain models mentioned above compared to MVIIA, and lower side effects. In addition, it blocks Cav2.2/CACNA1B more rapidly than MVIIA and also dissociates more rapidly.