Secreted aspartic protease 3

UniProtKB accession:  P0CY29

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors (PubMed:11478679, PubMed:19880183, PubMed:20713630, PubMed:23927842). These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense (PubMed:23927842, PubMed:11478679, PubMed:19880183). Induces host inflammatory cytokine production in a proteolytic activity-independent way (PubMed:20713630). Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein (PubMed:23927842).