DNA-binding dual transcriptional regulator OmpR

UniProtKB accession:  P0AA16

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes (PubMed:3010044, PubMed:3536870). Plays a central role in both acid and osmotic stress responses (PubMed:28526842, PubMed:30524381). Binds to the promoter of both ompC and ompF; at low osmolarity it activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription (PubMed:3533941, PubMed:3023382, PubMed:2557454, PubMed:2403550, PubMed:7592927). Involved in acid stress response; this requires EnvZ but not OmpR phosphorylation (PubMed:29138484). Phosphorylated by EnvZ; this stimulates OmpR's DNA-binding ability (PubMed:2656684, PubMed:2668281, PubMed:2668953, PubMed:2674113, PubMed:2558046, PubMed:7934854). Is also dephosphorylated by EnvZ (PubMed:2668281, PubMed:2558046, PubMed:7934854). A single OmpR protein can bind to DNA; OmpR dimers can form on the DNA in either direction, suggesting that interactions between the 2 DNA-binding domains are weak or absent (PubMed:18195018).