Bifunctional aldehyde-alcohol dehydrogenase AdhE

UniProtKB accession:  P0A9Q7

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UniProtKB description:  Under fermentative conditions, catalyzes the sequential NADH-dependent reduction of acetyl-CoA to acetaldehyde and then to ethanol (PubMed:6752127, PubMed:2015910, PubMed:10612730, PubMed:10922373, PubMed:17280641). Under aerobic conditions, despite the reversibility of the two NADH-coupled reactions, wild-type E.coli cannot grow on ethanol as the sole carbon and energy source due to the down-regulation of adhE transcription and the inactivation of the enzyme by metal-catalyzed oxidation (MCO) (PubMed:10922373). Nevertheless, in the presence of oxygen, AdhE may act as a hydrogen peroxide scavenger and have a protective role against oxidative stress (PubMed:12783863).