Serine hydroxymethyltransferase

UniProtKB accession:  P0A825

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UniProtKB description:  Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules (PubMed:3891721, PubMed:1517215, PubMed:7925461, PubMed:10858298, PubMed:19883126). Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of allothreonine and 3-phenylserine (PubMed:3891721, PubMed:1517215, PubMed:10858298, PubMed:19883126). Also catalyzes the irreversible conversion of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate (PubMed:2201683, PubMed:10858298).