Homeotic protein bicoid

UniProtKB accession:  P09081

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Segment polarity transcription factor that provides positional cues for the development of head and thoracic segments (PubMed:2901954, PubMed:24637116, PubMed:35363606). Forms a protein concentration gradient that patterns the anterior-posterior axis during embryogenesis and promotes the expression of anterior gap genes, such as hunchback (hb), ocelliless (oc), and buttonhead (btd) (PubMed:2901954, PubMed:24637116, PubMed:35363606). Binds to regulatory DNA sequences containing a 5'-TAATCC-3' sequence motif (PubMed:16406070, PubMed:35363606). Also binds RNA (PubMed:2752425). Interacts with Bin1 to repress transcription of bicoid target genes in the anterior tip of the embryo; a process known as retraction (PubMed:11455422).