Genome polyprotein

UniProtKB accession:  P08617

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Capsid proteins VP1, VP2, and VP3 form a closed capsid enclosing the viral positive strand RNA genome (PubMed:25327248, PubMed:28074040). All these proteins contain a beta-sheet structure called beta-barrel jelly roll (PubMed:25327248). Together they form an icosahedral capsid (T=3) composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms (PubMed:25327248). VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes (PubMed:25327248). The naked capsid interacts with the host receptor HAVCR1 to provide virion attachment to and probably entry into the target cell (PubMed:9658108, PubMed:11134285, PubMed:29437974).