Holin

UniProtKB accession:  P06808

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron-scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space (PubMed:11255004). Determines the precise timing of host cell lysis (PubMed:22389108). Regulated by specific antiholins that somehow sense superinfections and then delay lysis (PubMed:16166524, PubMed:22389108, PubMed:27381920, PubMed:34456892, PubMed:32562709). Participates with the endolysin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell.