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65 kDa phosphoprotein

UniProtKB accession:  P06725
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Go to UniProtKB:  P06725
UniProtKB description:  Counteracts the host antiviral immune response when activated and phosphorylated, by preventing host IRF3 from entering the nucleus (PubMed:15452220). Inhibits also the type I interferon production by inactivating the enzymatic activity of DNA sensor CGAS without affecting STING1 (PubMed:29263269). Participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes (PubMed:20504932).
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