Tegument protein VP16

UniProtKB accession:  P06492

Grouped By:  Matching UniProtKB accession

UniProtKB description:  In the early stage of viral replication, acts as a transcriptional activator of immediate-early (IE) gene products (alpha-genes), which is released by invading virions (PubMed:23029222, PubMed:12826401). Recruits P-TEFb to the viral alpha-gene promoters and overcomes transcriptional inhibition by ICP22 to promote transcription of IE genes (PubMed:23029222, PubMed:15654739). VP16-induced complex represents a regulatory switch: when it is on, it promotes IE-gene expression and thus lytic infection, and when it is off, it limits IE-gene transcription favoring latent infection (PubMed:12826401). Acts as a key activator of lytic infection by initiating the lytic program through the assembly of the transcriptional regulatory VP16-induced complex composed of VP16 and two cellular factors, HCFC1 and POU2F1 (PubMed:10398682). This complex recognizes the core motif 'TAATGARAT' in alpha-gene promoters (PubMed:12826401). In the late stage of viral replication, VP16, as a tegument, is involved in viral assembly (PubMed:19279114).