Epstein-Barr nuclear antigen 6

UniProtKB accession:  P03204

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UniProtKB description:  Plays an essential role for the activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Targets host chromatin through interactions with host transcription factors, especially RBPJ and IRF4 (PubMed:8627785, PubMed:26719268). Alternatively, EBNA6 also regulates the transcription of the EBV oncogene LMP1 in a cell cycle-dependent manner. Modulates the activity of several host proteins involved in cell cycle regulation including host cyclin A, MYC, RB, p21 and p27 mainly through binding to the host SCF(SKP2) complex (PubMed:16352731). Inhibits the promoter of host H2AX and targets H2AX to proteasomal degradation in order to promote latency and cell proliferation (PubMed:24429368). Upregulates host PIM1 expression and stabilization (PubMed:25121590). Potentiates PIM1 to promote cell proliferation by inhibiting the growth suppressive properties of p21 (PubMed:25121590).