Aminopeptidase N

UniProtKB accession:  O96935

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Displays aminopeptidase activity with a broad substrate specificity (PubMed:9879894, PubMed:12166515, PubMed:21659511, PubMed:22359643, PubMed:34133730, PubMed:33536500, PubMed:19196988, PubMed:21844374, PubMed:23897806). Preferentially, cleaves after Leu and Met, but cleaves also after Ala and Arg (PubMed:12166515, PubMed:22359643, PubMed:33536500, PubMed:21844374). Low activity towards Lys, Phe, Tyr, Trp, Gln, Ser and Gly and negligible activity towards Glu, Asp, Pro, Ile, Thr, Val, His and Asn (PubMed:22359643). Has dipeptidase activity (PubMed:21659511, PubMed:23897806). Plays a role in the terminal stages of host hemoglobin digestion by cleaving the N-terminal residue of small hemoglobin-derived oligopeptides (PubMed:21659511, PubMed:34133730, PubMed:21844374).