Ubiquitin-activating enzyme E1 1

UniProtKB accession:  O94609

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP.