Cryptochrome-1

UniProtKB accession:  O77059

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Blue light-dependent regulator that is the input of the circadian feedback loop (PubMed:9845369, PubMed:10063806, PubMed:10233998, PubMed:10417378, PubMed:16527739, PubMed:17298948, PubMed:18597555, PubMed:36994075). Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts (PubMed:10063806). Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms (PubMed:9845369, PubMed:10063806, PubMed:10233998). Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells (PubMed:9845370, PubMed:10417378, PubMed:16527739, PubMed:36994075). Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry (PubMed:10417378, PubMed:16527739). Necessary for light-dependent magnetosensitivity, an intact circadian system is not required for the magnetoreception mechanism to operate (PubMed:18641630). Required for both the naive and trained responses to magnetic field, consistent with the notion that cry is in the input pathway of magnetic sensing (PubMed:18641630).