A disintegrin and metalloproteinase with thrombospondin motifs 4
UniProtKB accession: O75173
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Go to UniProtKB: O75173
UniProtKB description: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
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