Protein argonaute

UniProtKB accession:  O67434

Grouped By:  Matching UniProtKB accession

UniProtKB description:  A DNA-guided RNA endonuclease. Uses short ssDNA sequences as guides (gDNA) to bind complementary target strands, resulting in cleavage of the target RNA. The cleavage site is 10 nucleotides downstream of the residue base paired with the 5'-end of the gDNA (PubMed:16061186). Binds ssDNA better than ssRNA, binds dsDNA and DNA-RNA hybrids but does not bind dsRNA (PubMed:16061186). A 2 nucleotide 3'-overhang (possibly on the guide strand) may help load nucleic acids into the complex (PubMed:17027504) (Probable).