Transcriptional regulator peptide PatS

UniProtKB accession:  O52748

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Inhibits heterocyst differentiation; a peptide corresponding to the last 5-6 amino acids blocks heterocyst formation when added exogenously in culture. Controls heterocyst pattern formation through intercellular signaling mechanisms. In Nostoc filaments, approximately every 10th vegetative cell terminally differentiates into a heterocyst specialized for nitrogen fixation. Seems to inhibit the formation of adjacent heterocysts (PubMed:9794762, PubMed:11274121, PubMed:15051891). The C-terminal peptide binds HetR, inhibits hetR transcription and blocks the DNA-binding of HetR. Peptide binding to HetR alters its conformation, probably leading to dissociation of the HetR-DNA complex and cessation of transcription (PubMed:26576507).