2',3'-cyclic-nucleotide 2'-phosphodiesterase

UniProtKB accession:  O31775

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UniProtKB description:  Plays a central, regulatory role in the late adaptive responses and affects the levels of many genes (PubMed:24163345). May act via regulation of cAMP levels (PubMed:26904951). Decreases the expression of motility genes and induces genes involved in biofilm formation, by controlling the expression of SlrR (PubMed:21856853). Required for formation of intercellular nanotubes that bridge neighboring cells to allow molecular exchange (PubMed:26906740). Plays a key role in directing the early stages of colony development (PubMed:26904951). In vitro, has a metal-dependent phosphodiesterase activity against 2',3'-cAMP and 2',3'-cGMP. Has also 3',5'-cyclic-nucleotide phosphodiesterase activity, but cannot use cyclic di-AMP or cyclic di-GMP, and does not have phosphatase activity (PubMed:24163345).