4-coumarate--CoA ligase 2

UniProtKB accession:  O24146

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UniProtKB description:  Major enzyme of the phenylpropanoid pathway that mediates the production of several precursors for numerous metabolites and regulates carbon flow (PubMed:26412334). Catalyzes the formation of CoA thioesters using 4-coumarate, ferulate, caffeate, and cinnamate as substrates (PubMed:8819324, PubMed:26412334). Follows a two-step reaction mechanism, wherein a (hydroxy)cinnamate substrate first undergoes adenylation by ATP leading to an acyl-AMP, followed by a thioesterification in the presence of CoA to yield the final (hydroxy)cinnamoyl-CoA product (PubMed:26412334). Almost inactive toward sinapate (PubMed:8819324, PubMed:26412334).