Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 1

UniProtKB accession:  O23530

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Disease resistance protein of the TIR-NB-LRR-type (PubMed:14576290). Part of the RPP5 locus that contains a cluster of several paralogous disease resistance (R) genes (PubMed:14576290). Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein (PubMed:14576290). That triggers a defense system including the hypersensitive response, which restricts the pathogen growth (PubMed:14576290). Probably acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death (PubMed:31439792). Expression regulated by MOS1 at chromatin level (PubMed:20647385). Nuclear localization of SNC1 is essential for its activity (PubMed:22454454). ABA deficiency can rescue high-temperature inhibition of SNC1-mediated defense responses (PubMed:22454454).