Multiprotein-bridging factor 1

UniProtKB accession:  O14467

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters (PubMed:9710580). Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation (PubMed:30465652, PubMed:36583309). Required to prevent stalled ribosomes from frameshifting (PubMed:30465652, PubMed:36583309).