Bifunctional lipase/adenylate cyclase LipJ

UniProtKB accession:  O07732

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UniProtKB description:  May play a role in cell wall modulation (PubMed:33960821, PubMed:34019937). The N-terminal domain exhibits lipolytic activity (PubMed:33960821). In vitro, hydrolyzes various p-nitrophenyl (pNP) esters (PubMed:33960821). pNP-decanoate (C10) is the best substrate, followed by pNP-octonate (C8), pNP-laurate (C12) and pNP-butyrate (C4) (PubMed:33960821). Exhibits lower activity with pNP-acetate (C2), pNP-myristate (C14) and pNP-palmitate (C16) (PubMed:33960821). Can also use tributyrin (PubMed:33960821). The C-terminal domain catalyzes the biosynthesis of cyclic AMP (cAMP) from ATP (PubMed:15678099). It has a guanylyl cyclase side-activity, corresponding to 7% of the adenylate cyclase activity (PubMed:15678099).