RNA-binding protein pos-1

UniProtKB accession:  G5EF15

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UniProtKB description:  RNA-binding protein that coordinates cell fate specification and differentiation during early embryogenesis (PubMed:9834181, PubMed:23034181). Binds to a consensus pos-1 recognition element (PRE) consisting of the sequence 5'-UA(U 2-3)RGD(N 1-3)G-3', where R is any purine, D is A, G, or U, and N is any base (PubMed:18952820, PubMed:23034181). The PRE motif is found within the 3' untranslated region of many maternal transcripts required for early development (PubMed:18952820). Binds to the 3' untranslated region (UTR) of Notch receptor homolog glp-1, thereby repressing glp-1 translation in the posterior blastomeres in the embryo (PubMed:12702662, PubMed:23034181). Binding to glp-1 3' UTR excludes cell fate regulator gld-1 binding to an overlapping binding site in the glp-1 3' UTR (PubMed:23034181). Binds to the neg-1 3'UTR thereby opposing neg-1 expression and cytoplasmic polyadenylation of the neg-1 mRNA poly(A) tail promoted by gld-2 and gld-3 (PubMed:26096734). By inhibiting the cytoplasmic lengthening of neg-1 mRNA, restricts the accumulation of neg-1 protein and promotes endo-mesoderm development in anterior blastomeres (PubMed:26096734). Essential for germline specification (PubMed:9834181).