Transcription factor AmrZ
UniProtKB accession: G3XCY4
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Go to UniProtKB: G3XCY4
UniProtKB description: Functions both as a transcriptional activator and a repressor of multiple genes encoding virulence factors as well as genes involved in environmental adaptation (PubMed:16352829, PubMed:26549743, PubMed:22511872). Plays a role in alginate production via the activation of AlgD which is the first gene in the alginate biosynthetic operon (PubMed:16352829, PubMed:10476040). Regulates also the transcription of genes responsible for type IV pili localization and twitching motility (PubMed:16352829). Mediates transition of P.aeruginosa biofilm infections from colonizing to chronic biofilms through repression of the psl operon (PubMed:23354748). Represses also its own transcription by binding to two sites on amrZ promoter, amrZ1 and amrZ2 (PubMed:15968052).
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