VIRF-1

UniProtKB accession:  F5HF68

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Plays a role in the inhibition of host innate response by repressing the expression of interferon-inducible genes and blocking host IRF1- and IRF3-mediated transcription. Blocks the interaction between host IRF3 and CREBBP. Regulates the host cellular metabolism by increasing glucose uptake, ATP production and lactate secretion through down-regulation of heterogeneous nuclear ribonuclear protein Q1/SYNCRIP. Mechanistically, induces ubiquitination and degradation of SYNCRIP through the ubiquitin-proteasome pathway by recruiting KLHL3/CUL3 ubiquitin ligase complex (PubMed:35538151). Disrupts host TP53 signaling pathway during viral infection by interacting with host USP7 and thereby decreasing the availability of USP7 for deubiquitinating and stabilizing TP53 (PubMed:26786098). Plays a role in the global inhibition of protein ISGylation by interacting with host HERC5 leading to its inhibition (PubMed:26355087). Promotes its own propionylation by blocking SIRT6 interaction with ubiquitin-specific peptidase 10/USP10 leading to SIRT6 degradation via a ubiquitin-proteasome pathway (PubMed:37023208). In turn, propionylation is required to block IRF3-CBP/p300 recruitment and to repress the STING DNA sensing pathway (PubMed:37023208). Plays a role in the activation of mitophagy during infection via interaction with the host proteins NIX/BNIP3L, TUFM and GABARAPL1 thereby inhibiting antiviral responses and contributing to productive replication (PubMed:31324791, PubMed:37459327).