Holliday junction branch migration ATPase PINA

UniProtKB accession:  F0NID4

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UniProtKB description:  Promotes Holliday junction (HJ) branch migration and unwinds Y-shaped DNA (but not replication forks or dsDNA) in an ATP hydrolysis-dependent manner (PubMed:28238763). Stimulates cleavage by HJ resolvase Hjc (PubMed:28238763). Unwinds Y-shaped and 3'-flap DNA substrates. In the absence of other proteins stabilizes replication forks (prevents spontaneous unwinding); Hjc, Hjm (Hel308) and PINA coordinate HJ migration and cleavage of replication forks in a coordinated way (PubMed:29846688). Inhibits the 5'-3' (but not 3'-5') helicase activity of helicase Hjm (Hel308) on overhang DNA (PubMed:29846688). Probably acts as an ATP-dependent pump that pulls DNA through the hexamer (By similarity).