Thebaine 6-O-demethylase

UniProtKB accession:  D4N500

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Non-heme dioxygenase involved in biosynthesis of morphinan-type benzylisoquinoline and opiate alkaloids natural products (PubMed:29779229, PubMed:20228795). Mediates the conversion of thebaine to neopinone (PubMed:20228795, PubMed:22098111). Catalyzes also, with lower efficiency, the 6-O-demethylation of oripavine to neomorphinone, which is converted spontaneously to morphinone (PubMed:20228795, PubMed:29779229). Supports dealkylation reactions such as O,O-demethylenation in the metabolism of protopine, benzo[c]phenanthridine, and rhoeadine alkaloids; cleaves a methylenedioxy bridge leaving two hydroxyl groups (PubMed:23928311). Catalyzes the O-demethylation of methylenedioxy bridges on protopine alkaloids such as allocryptopine (PubMed:23928311). No activity with (S)-reticuline, salutaridine, papaverine, (S)-corytuberine, (S)-scoulerine, pavine, noscapine or codeine (PubMed:20228795).