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Flavin-dependent monooxygenase

UniProtKB accession:  D3HKY4
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Go to UniProtKB:  D3HKY4
UniProtKB description:  An FAD-requiring monooxygenase active on tetracycline antibiotic and some of its derivatives, which leads to their inactivation (PubMed:26097034). Expression in E.coli confers high resistance to tetracycline and oxytetracycline, does not confer resistance to minocycline or tigecycline. The reaction requires NADPH (PubMed:26097034). Expression in L.pneumophila confers resistance to tetracycline (PubMed:28481346). Degrades and confers resistance to tetracycline and chlortetracycline (PubMed:26097034, PubMed:28481346).
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