Palustrin-Ca

UniProtKB accession:  C5IB03

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Antibacterial peptide with amphipathic alpha-helical structure that exhibits potent broad-spectrum activity against Gram-positive and -negative bacteria (Ref.1, PubMed:34789753). It is active against Listeria ATCC 54004 (MIC=30 ug/ml), S.aureus ATCC 25923 (MIC=7.8 ug/ml), S.suis 2 CVCC 606 (MIC=31.25 ug/ml), B.subtilis ADB403 (30 ug/ml), K.pneumoniae ATCC 700603 (MIC=60 ug/ml) and P. aeruginosa ATCC 227853 (MIC=30 ug/ml) (Ref.1). Does not show activity against Salmonella ATCC 20020 and the fungus Candida albicans (Ref.1). Is also cytotoxic to HeLa cells at high concentrations (Ref.1). In addition, shows a strong antitumor activity but only a little hemolytic activity (Ref.1). Despite the presence of a Gly residue at position 10, this alpha-helical peptide remains relatively rigid, not exhibiting any significant flexibility during the molecular dynamics simulation (PubMed:34789753). The peptide shows a preference for a position parallel to the target membrane that suggests it exerts its antimicrobial activity through a non-pore-forming mechanism of action, such as the carpet model or the interfacial activity model (PubMed:34789753).