Vitamin D(3) 25-hydroxylase

UniProtKB accession:  C4B644

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UniProtKB description:  Hydroxylates vitamin D(3) into 25-hydroxyvitamin D(3) and 1-alpha,25-dihydroxyvitamin D(3), its physiologically active forms. It first hydroxylates the C-25 position of vitamin D(3) to form 25-hydroxyvitamin D(3), then subsequently hydroxylates the C-1-alpha position to form 1-alpha,25-dihydroxyvitamin D(3). Also displays 25-hydroxylase activity on vitamin D(2) and 7-dehydrocholesterol. May play a role in the biosynthesis of steroid metabolic intermediates.