Cyclotide hyen-D

UniProtKB accession:  C0HLN8

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UniProtKB description:  Probably participates in a plant defense mechanism (By similarity). Has strong cytotoxic activity against HUVEC cells (LC(50)= 0.58 uM) and various cancer cells including HeLa (LC(50)= 0.48 uM), MCF-7 and K562 (PubMed:32414842). Also displays some hemolytic activity (PubMed:32414842). Binds to and induces leakage in phospholipd membranes, particularly ones containing 1-palmitoyl-2-oleophosphatidylethanolamine (POPE) (PubMed:32414842).